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| Registros recuperados: 3.453 | |
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| Russ B. Altman. |
| This is a powerpoint presentation made initially at the Cold Spring Harbor meeting on Pharmacogenomics, November 2006. It discusses the PharmGKB (http://www.pharmgkb.org/) and how we are building a pipeline for annotation of knowledge. In particular, we are focusing on pathway knowledge, "Very important Pharmacogene" annotations, and curation of the pharmacogenomics literature. We are building an ontology-based system to capture and aggregate knowledge, for use by our curators. |
| Tipo: Presentation |
Palavras-chave: Biotechnology; Genetics & Genomics; Pharmacology. |
| Ano: 2006 |
URL: http://precedings.nature.com/documents/8/version/1 |
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| Nicolas Le Novere; Eric Fernandez; Renaud Schiappa; Jean-Antoine Girault. |
| Integration of neurotransmitter and neuromodulator signals in the striatum plays a central role in the functions and dysfunctions of the basal ganglia. DARPP-32 is a key actor of this integration in the GABAergic medium-size spiny neurons, in particular in response to dopamine and glutamate. When phosphorylated by cAMP-dependent protein kinase (PKA) DARPP-32 inhibits protein phosphatase-1 (PP1), whereas when phosphorylated by cyclin-dependent kinase 5 (CDK5) it inhibits PKA. DARPP-32 is also regulated by casein kinases and by several protein phosphatases. These complex and intricate regulations make simple predictions of DARPP-32 dynamic behaviour virtually impossible. We used detailed quantitative modelling of the regulation of DARPP-32 phosphorylation to... |
| Tipo: Poster |
Palavras-chave: Neuroscience. |
| Ano: 2006 |
URL: http://precedings.nature.com/documents/9/version/1 |
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| Nicolas Le Novere. |
| The practise of Systems Biology relies on interfaces. Interfaces
between the entities we study: the paradigm moved from a physical
object centric view toward a relationship-centric one; interfaces
between tools: From the retrieval of the primary data to the fine
analysis of a model's behaviour, one uses many tools, more or less
well connected; interfaces between individuals: To build any
non-trivial mechanistic model requires to merge existing work and
gather external expertise.

If we want these interfaces to be generic enough to allow for anybody
to leverage on existing... |
| Tipo: Presentation |
Palavras-chave: Biotechnology; Data Standards. |
| Ano: 2006 |
URL: http://precedings.nature.com/documents/10/version/1 |
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| Jan G. Bjaalie. |
| The Global Science Forum (GSF) of the OECD has initiated a new international organization, INCF, to further the development of Neuroinformatics as a global effort with the support of all ministers of research within OECD. This presentation explains the background for the establishment of the INCF, outlines some of the goals, and defines the operations of the INCF Secretariat in relation the INCF National nodes and the general neuroscience community. |
| Tipo: Presentation |
Palavras-chave: Neuroscience. |
| Ano: 2006 |
URL: http://precedings.nature.com/documents/7/version/1 |
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| Gabriel Leitner; Ana-Maria Anug; Uzi Merin; Nissim Silanikove. |
| *Background*
Repeated research findings over the last 4 decades show that involution of mammary glands in dairy cows did not regress to same extend as that noticed in other mammalian species.

*Methodology/Principal Findings*
We took an advantage of a rare event in the normal modern dairy farming: A cow that was false-positively identified as being pregnant was "dried up" (i.e., induced into involution) conventionally about 60 before her expected parturition. This cow was culled, and samples of her mammary gland tissue were examined for gross histology. In this study we demonstrate for the first time that modern dairy cow may undergo extensive obliteration of the... |
| Tipo: Manuscript |
Palavras-chave: Cancer; Developmental Biology; Immunology. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/846/version/2 |
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| Etienne Joly. |
| To obtain an optimised form of BFP for use as a reporter gene in mammalian cells, the brightest available GFP form, EGFP, was mutated at 5 different positions, yielding 8 different mutagenised forms of BFP. The intensity of the fluorescent signals attained in mammalian cells with all these various versions of BFP was analysed by flow cytometry of transiently transfected COS 7 cells. The best mutant obtained can be detected readily both by flow cytometry and fluorescence microscopy, even when expressed together with GFP. To explore whether cellular localization could enhance the fluorescence signals any further, plasmid constructs were made to target optimised versions of GFP and BFP to the nucleus, the endoplasmic reticulum (ER) and the cell surface.... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/1259/version/1 |
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| Romulus Breban; Virginie Supervie; Justin Okano; Raffaele Vardavas; Sally Blower. |
| The Centers for Disease Control (CDC) is currently attempting to eliminate syphilis in the United States (US); to ensure that their control strategies will be effective it is important to understand the transmission dynamics of syphilis. Epidemics of certain infectious diseases (e.g., influenza) can rise and fall with a well-defined periodicity; this cycling behavior is important because it can have significant implications for the design and effectiveness of control strategies. Here we discuss the methodology that has been used to identify epidemic cycles in longitudinal data sets, and the endogenous and exogenous mechanisms that generate cycling. We then examine the recently proposed hypothesis that syphilis epidemics cycle. This hypothesis was proposed... |
| Tipo: Manuscript |
Palavras-chave: Ecology. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/1373/version/1 |
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| Daniel Casasanto. |
| If understanding action words involves mentally simulating our own actions, then the neurocognitive representation of word meanings must differ for people with different kinds of bodies, who perform actions in systematically different ways. In a test of the _Body-Specificity Hypothesis_, right- and left-handers were compared on two motor-meaning congruity tasks. Double dissociations in both action execution and recognition memory results showed that right and left handers form body-specific representations of words for manual actions. |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/1321/version/1 |
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| Xin Wang; Shaolin Zheng. |
| Despite of angiosperms in the Yixian Formation (>125 Ma, early Cretaceous), there is no perfect flower typical of angiosperms to date. Here we report _Euanthus dilaensis_ gen. et sp. nov as the earliest perfect flower known to date. The flower includes tepals, androecium and gynoecium. The anthers are globose in form, with bristles atop and in situ round-triangular pollen grains. The gynoecium is composed of probably two carpels with plumose stigmas and a carpel-enclosing receptacle. The discovery of _Euanthus_ increases the diversity of early angiosperms, and indicates that perfect flowers occurred as early as 125 Ma ago.
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| Tipo: Manuscript |
Palavras-chave: Ecology; Evolutionary Biology. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/1320/version/1 |
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| Flávio Codeço Coelho; Claudia Codeco; Oswaldo Cruz. |
| The construction of complex statial simulation models such as those used in network epidemiology, is a daunting task due to the large amount of data involved in their parameterization. Such data, which frequently resides on large geo-referenced databases, has to be processed and assigned to the various components of the model. All this just to construct the model, then it still has to be simulated and analyzed under different epidemiological scenarios. This workflow can only be achieved efficiently by computational tools that can automate most if not all these time-consuming tasks. In this paper, we present a simulation software, Epigrass, aimed to help designing and simulating network-epidemic models with any kind of node behavior.
... |
| Tipo: Manuscript |
Palavras-chave: Bioinformatics. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/378/version/1 |
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| Adeilton Brandao. |
| With the thousands of scientific papers being produced every month, picking an authors name, associate it to a research field and right evaluate his or her performance is in most of times a cumbersome task. I am proposing here that science indexes as h-index, g-index, total citations and published papers could be added to biomedical bibliographic citation in order to create a unique identifier for a given researcher. |
| Tipo: Manuscript |
Palavras-chave: Bioinformatics. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/794/version/1 |
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| Alex J. Cannon. |
| Statistical downscaling models are used to estimate weather data at a station or stations based on atmospheric circulation data defined at a coarser resolution, for example gridded outputs from a Global Climate Model (GCM). Downscaled data can be used as inputs to environmental models that require finer-scale climate fields than are currently available from GCMs. Maintaining realistic downscaling relationships between sites and variables is particularly important in hydrological models, as streamflow depends strongly on the spatial distribution of precipitation in a watershed and on interactions with temperature that determine whether precipitation falls as rain or snow. More generally, precipitation is a difficult variable to downscale because of its... |
| Tipo: Presentation |
Palavras-chave: Earth & Environment. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/446/version/1 |
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| Robert Muetzelfeldt. |
| Most simulation models in ecological and environmental research are implemented as computer programs in a conventional programming language. This brief paper argues for a radically different approach, based on the representation of the model structure, relationships and equations in a declarative format (e.g. XML). Simulation code can then be generated from this, but in addition the model can be displayed and processed in a wide range of useful ways, greatly increasing the efficiency and effectiveness of the modelling process. |
| Tipo: Manuscript |
Palavras-chave: Ecology; Earth & Environment. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/17/version/1 |
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| Diana D. E. Marco; Sergio S. A. Cannas; Marcelo M. A. Montemurro; Bo Hu; Shiyuan Cheng. |
| The invariance of some system properties over a range of temporal and/or spatial scales is an attribute of many processes in nature1, often characterised by power law functions and fractal geometry2. In particular, there is growing consensus in that fat-tailed functions like the power law adequately describe long-distance dispersal (LDD) spread of organisms 3,4. Here we show that the spatial spread of individuals governed by a power law dispersal function is represented by a clear and unique signature, characterised by two properties: A fractal geometry of the boundaries of patches generated by dispersal with a fractal dimension D displaying universal features, and a disrupted patch size distribution characterised by two different power laws. Analysing... |
| Tipo: Manuscript |
Palavras-chave: Cancer; Ecology. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/907/version/1 |
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| Sebastian Bassi; Virginia Gonzalez. |
| Checksum algorithms are used in biological databases for integrity check and identification purposes. CRC64 is the only checksum algorithm already included in Biopython. This work proposes two new implementation of known algorithms (GCG Checksum and SEGUID). There is also an application based on SEGUID: Looking for redundancy between two FASTA files full of protein sequences based only in sequence information, by comparing the SEGUIDs of both files.
The code is shown in the manuscript and may be available at Biopython.org. |
| Tipo: Presentation |
Palavras-chave: Bioinformatics. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/278/version/1 |
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| Diego Mauricio Riaño-Pachón; Luiz Gustavo Guedes Correa; Bernd Mueller-Roeber. |
| PlnTFDB is a publicly available computational resource comprising putative complete sets of transcription factors from plants. The original database listed the putative complete sets of TFs from five different green plant (viridiplantae) species. Up to date, summer 2007, PlnTFDB have had more than one hundred thousand hits from more than one thousand different clients, showing the importance that this resource had acquired for the plant community. In this first major update, we extended the coverage of the database to additional completed viridiplantae genomes, i.e., the moss _Physcomitrella patens_ and the rice _Oryza sativa_ spp _indica_. The scope of PlnTFDB was broadened to encompass other eukaryote photosynthetic organisms, such as the rhodophyte... |
| Tipo: Poster |
Palavras-chave: Ecology; Bioinformatics; Plant Biology. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/1094/version/1 |
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| Chien-Hui Liou; Chang-Wei Hsieh; Chao-Hsien Hsieh; Si-Chen Lee; Jyh-Horng Chen; Chi-Hong Wang. |
| The human brain possesses plenty of functions but little is known about its scientific relationship with mind and spirit. Conferences^1,2^ focused on the connection between science and religion were held very recently in which neuroscientists, Buddhist scholars and Dalai Lama discussed attention, mental imagery, emotion, mind, brain functions and meditation, suggesting religious meditation offers an effective means to investigate the mystery of mind and spirit. In the past decade, scientists struggled to obtain brain mappings for various meditation styles using different brain imaging techniques and stimulating results have been observed^3-17^. In this letter we report that, together with other brain regions, pineal body... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/1328/version/1 |
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| Matthias Samwald. |
| Dystroglycan is part of a large complex of proteins, the dystrophin-glycoprotein complex, which has been implicated in the pathogenesis of muscular dystrophies for a long time. Besides muscular degeneration many patients manifest symptoms of neurological and cognitive dysfunction. Newer findings suggest that dystroglycan is implicated in brain development, synapse formation and plasticity, nerve-glia interactions and maintenance of the blood-brain barrier.
Most research so far has focused on the functions of dystroglycan in muscle and neuromuscular junctions, while its role in the brain and interneuronal synapses has been largely neglected. 
This review will give an overview of the biochemistry of dystroglycan, its... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/196/version/1 |
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| Spencer D. Heringa; Jonathan D. Monroe; James B. Herrick. |
| We are studying the lateral transfer of transmissible antibiotic resistance plasmids among stream bacteria impacted by fecal runoff from poultry and cattle. Such plasmids are typically large (ca. 40 – 100 kb) and occur in low copy numbers in the cell and have therefore typically been difficult to isolate and therefore to study. Traditional protocols, based upon variations of the standard alkaline-lysis method, are long (ca. 1 1/2 to 2 days) and difficult. Commercial kits designed for the isolation of Baterial Artificial Chromosomes (BACs) can be used and are an improvement; however, these are expensive and still require hours of sustained effort. We have adapted a method published by Rondon et al. (1999), originally designed for the isolation of... |
| Tipo: Poster |
Palavras-chave: Biotechnology; Genetics & Genomics; Microbiology. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/1249/version/1 |
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| Registros recuperados: 3.453 | |
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